What are some strategies if lifestyle changes are not enough?
We start by looking at their specific predominant symptom complex. For a patient with IBS and constipation who doesn't respond to fiber, laxatives may be of use. We try to avoid the stimulant laxatives because there are some concerns about long-term safety, so we use osmotic laxatives, which work by drawing water into the colon. Medications are also available that bind to receptors for serotonin, a chemical in the gut that stimulates the bowel to work better.
How is IBS with diarrhea treated differently?
If a patient's diarrhea does not respond to fiber, then we may try anti-spasmotic medications to slow the gut down by relaxing the smooth muscle of the colon. To some extent, by reducing the contractility of the colon, they also reduce the discomfort.
In patients who have diarrhea, but primarily complain about pain, we might use antidepressant medications that have some pain modulating effects. There are also serotonergic drugs available for the treatment of diarrhea, but they tend to be reserved for younger patients with very severe diarrhea who have tried many medications and don't get better.
What is there a role for mental health counseling for IBS?
Mental health counseling in the average IBS patient is probably not necessary, although it still may be beneficial because it may deal with some of the underlying psychosocial triggers for the IBS symptoms. But I don't that it is something that we should think about except in the minority of patients that have really severe symptoms. Some of these patients may also have a psychiatric disorder.
What new developments in the management of IBS can patients and their doctors look forward to?
I think this is a wonderful time in the course of IBS, particularly IBS therapy. There are drugs that work and there are education initiatives, so patients will start learning about these newer therapies. I'm excited about how patients are going to get better and am anxiously awaiting the newer therapies.